Syndactyly as part of a syndrome

Syndactyly is most commonly an isolated finding which we believe is “simply” related to a failure of the cells to regress during development.  This failure to regress means that the webspace does not develop ~ the 7th-8th week of gestation.  We know that the apical ectodermal ridge is involved and signaling mechanisms including FGF-8.  This […]

Tight First Webspace

 The space between the thumb and index (pointer) finger is crucial for function.  We say that the thumb accounts for 40% of hand function – much of that function is related to grasping large objects in this ‘first webspace’.   The thumb-index webspace, or as it is also called- the first webspace, can be tight or […]